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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide
The class Ic antiarrhythmic drug flecainide inhibits KCNH2-encoded “hERG” potassium channels at clinically relevant concentrations. The aim of this study was to elucidate the underlying molecular basis of this action. Patch clamp recordings of hERG current (I(hERG)) were made from hERG expressing ce...
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| Gepubliceerd in: | J Mol Cell Cardiol |
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| Hoofdauteurs: | , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Academic Press
2015
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4564290/ https://ncbi.nlm.nih.gov/pubmed/26159617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.021 |
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