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hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine
BACKGROUND: Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN‐channels. This study investigated the propensity of ivabradine to interact with KCNH2‐encoded human Ether‐à‐go‐go–Related Gene (hER...
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| Veröffentlicht in: | J Am Heart Assoc |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Ltd
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4579960/ https://ncbi.nlm.nih.gov/pubmed/25911606 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001813 |
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