hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

BACKGROUND: Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN‐channels. This study investigated the propensity of ivabradine to interact with KCNH2‐encoded human Ether‐à‐go‐go–Related Gene (hER...

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Detalles Bibliográficos
Publicado en:J Am Heart Assoc
Autores principales: Melgari, Dario, Brack, Kieran E., Zhang, Chuan, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S., Dempsey, Christopher E., Ng, G. André, Hancox, Jules C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579960/
https://ncbi.nlm.nih.gov/pubmed/25911606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001813
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