hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

BACKGROUND: Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN‐channels. This study investigated the propensity of ivabradine to interact with KCNH2‐encoded human Ether‐à‐go‐go–Related Gene (hER...

Full description

Saved in:
Bibliographic Details
Published in:J Am Heart Assoc
Main Authors: Melgari, Dario, Brack, Kieran E., Zhang, Chuan, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S., Dempsey, Christopher E., Ng, G. André, Hancox, Jules C.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2015
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579960/
https://ncbi.nlm.nih.gov/pubmed/25911606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001813
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items