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hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

BACKGROUND: Ivabradine is a specific bradycardic agent used in coronary artery disease and heart failure, lowering heart rate through inhibition of sinoatrial nodal HCN‐channels. This study investigated the propensity of ivabradine to interact with KCNH2‐encoded human Ether‐à‐go‐go–Related Gene (hER...

詳細記述

保存先:
書誌詳細
出版年:J Am Heart Assoc
主要な著者: Melgari, Dario, Brack, Kieran E., Zhang, Chuan, Zhang, Yihong, El Harchi, Aziza, Mitcheson, John S., Dempsey, Christopher E., Ng, G. André, Hancox, Jules C.
フォーマット: Artigo
言語:Inglês
出版事項: Blackwell Publishing Ltd 2015
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579960/
https://ncbi.nlm.nih.gov/pubmed/25911606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.115.001813
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