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The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K(+) current I((Kr)). It has been suggested that low concentrations of erythromycin may have a protective effect against hER...

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Detalhes bibliográficos
Publicado no:Physiol Rep
Main Authors: El Harchi, Aziza, Butler, Andrew S., Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061092/
https://ncbi.nlm.nih.gov/pubmed/32147975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14385
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