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Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker
Cardiac potassium channels encoded by human ether-à-go-go–related gene (hERG) are major targets for structurally diverse drugs associated with acquired long QT syndrome. This study characterized hERG channel inhibition by a minimally structured high-affinity hERG inhibitor, Cavalli-2, composed of th...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5936838/ https://ncbi.nlm.nih.gov/pubmed/29545312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000363 |
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