Structural implications of hERG K(+) channel block by a high-affinity minimally structured blocker

Cardiac potassium channels encoded by human ether-à-go-go–related gene (hERG) are major targets for structurally diverse drugs associated with acquired long QT syndrome. This study characterized hERG channel inhibition by a minimally structured high-affinity hERG inhibitor, Cavalli-2, composed of th...

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Vydáno v:J Biol Chem
Hlavní autoři: Helliwell, Matthew V., Zhang, Yihong, El Harchi, Aziza, Du, Chunyun, Hancox, Jules C., Dempsey, Christopher E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936838/
https://ncbi.nlm.nih.gov/pubmed/29545312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000363
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