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Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants
The antianginal drug ranolazine, which combines inhibitory actions on rapid and sustained sodium currents with inhibition of the hERG/I(Kr) potassium channel, shows promise as an antiarrhythmic agent. This study investigated the structural basis of hERG block by ranolazine, with lidocaine used as a...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Academic Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121676/ https://ncbi.nlm.nih.gov/pubmed/24877995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.05.013 |
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