Llwytho...
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (I(Kr)). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell pat...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | Biochem Pharmacol |
|---|---|
| Prif Awduron: | , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Elsevier Science
2016
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959829/ https://ncbi.nlm.nih.gov/pubmed/27256139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.05.013 |
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