Carregant...
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking
The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (I(Kr)). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell pat...
Guardat en:
| Publicat a: | Biochem Pharmacol |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier Science
2016
|
| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4959829/ https://ncbi.nlm.nih.gov/pubmed/27256139 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.05.013 |
| Etiquetes: |
Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!
|