Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking

The antiarrhythmic drug amiodarone delays cardiac repolarisation through inhibition of hERG-encoded potassium channels responsible for the rapid delayed rectifier potassium current (I(Kr)). This study aimed to elucidate molecular determinants of amiodarone binding to the hERG channel. Whole-cell pat...

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Xehetasun bibliografikoak
Argitaratua izan da:Biochem Pharmacol
Egile Nagusiak: Zhang, Yihong, Colenso, Charlotte K., El Harchi, Aziza, Cheng, Hongwei, Witchel, Harry J., Dempsey, Chris E., Hancox, Jules C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier Science 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4959829/
https://ncbi.nlm.nih.gov/pubmed/27256139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.05.013
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