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High potency inhibition of hERG potassium channels by the sodium–calcium exchange inhibitor KB-R7943

BACKGROUND AND PURPOSE: KB-R7943 is an isothiourea derivative that is used widely as a pharmacological inhibitor of sodium–calcium exchange (NCX) in experiments on cardiac and other tissue types. This study investigated KB-R7943 inhibition of hERG (human ether-à-go-go-related gene) K(+) channels tha...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cheng, Hongwei, Zhang, Yihong, Du, Chunyun, Dempsey, Christopher E, Hancox, Jules C
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3413861/
https://ncbi.nlm.nih.gov/pubmed/21950687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01688.x
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