Ranolazine inhibition of hERG potassium channels: Drug–pore interactions and reduced potency against inactivation mutants

The antianginal drug ranolazine, which combines inhibitory actions on rapid and sustained sodium currents with inhibition of the hERG/I(Kr) potassium channel, shows promise as an antiarrhythmic agent. This study investigated the structural basis of hERG block by ranolazine, with lidocaine used as a...

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מידע ביבליוגרפי
Main Authors: Du, Chunyun, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
פורמט: Artigo
שפה:Inglês
יצא לאור: Academic Press 2014
נושאים:
Original Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121676/
https://ncbi.nlm.nih.gov/pubmed/24877995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.05.013
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