Modification by KCNE1 variants of the hERG potassium channel response to premature stimulation and to pharmacological inhibition

human Ether-à-go-go-Related Gene (hERG) encodes the pore-forming subunit of cardiac rapid delayed rectifier K(+) current (I(Kr)) channels, which play important roles in ventricular repolarization, in protecting the myocardium from unwanted premature stimuli, and in drug-induced Long QT Syndrome (LQT...

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Detalles Bibliográficos
Main Authors: Du, Chunyun, El Harchi, Aziza, Zhang, Henggui, Hancox, Jules C
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2013
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871485/
https://ncbi.nlm.nih.gov/pubmed/24400172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/phy2.175
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