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The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K(+) current I((Kr)). It has been suggested that low concentrations of erythromycin may have a protective effect against hER...

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Publicado en:Physiol Rep
Autores principales: El Harchi, Aziza, Butler, Andrew S., Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061092/
https://ncbi.nlm.nih.gov/pubmed/32147975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14385
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