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The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K(+) current I((Kr)). It has been suggested that low concentrations of erythromycin may have a protective effect against hER...

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Détails bibliographiques
Publié dans:Physiol Rep
Auteurs principaux: El Harchi, Aziza, Butler, Andrew S., Zhang, Yihong, Dempsey, Christopher E., Hancox, Jules C.
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7061092/
https://ncbi.nlm.nih.gov/pubmed/32147975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.14385
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