Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

The class Ic antiarrhythmic drug flecainide inhibits KCNH2-encoded “hERG” potassium channels at clinically relevant concentrations. The aim of this study was to elucidate the underlying molecular basis of this action. Patch clamp recordings of hERG current (I(hERG)) were made from hERG expressing ce...

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Foilsithe in:J Mol Cell Cardiol
Main Authors: Melgari, Dario, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Academic Press 2015
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Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564290/
https://ncbi.nlm.nih.gov/pubmed/26159617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.021
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