Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide

The class Ic antiarrhythmic drug flecainide inhibits KCNH2-encoded “hERG” potassium channels at clinically relevant concentrations. The aim of this study was to elucidate the underlying molecular basis of this action. Patch clamp recordings of hERG current (I(hERG)) were made from hERG expressing ce...

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Detaylı Bibliyografya
Yayımlandı:J Mol Cell Cardiol
Asıl Yazarlar: Melgari, Dario, Zhang, Yihong, El Harchi, Aziza, Dempsey, Christopher E., Hancox, Jules C.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Academic Press 2015
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4564290/
https://ncbi.nlm.nih.gov/pubmed/26159617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.06.021
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