Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D(2) Receptor Creates an Internalization-defective Receptor

af Clayton, Cecilea C., Donthamsetti, Prashant, Lambert, Nevin A., Javitch, Jonathan A., Neve, Kim A.
Udgivet i J Biol Chem (2014)

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

af Michino, Mayako, Beuming, Thijs, Donthamsetti, Prashant, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Udgivet i Pharmacol Rev (2015)

Using bioluminescent resonance energy transfer (BRET) to characterize agonist-induced arrestin recruitment to modified and unmodified G protein-coupled receptors (GPCRs)

af Donthamsetti, Prashant, Quejada, Jose Rafael, Javitch, Jonathan A., Gurevich, Vsevolod V., Lambert, Nevin A.
Udgivet i Curr Protoc Pharmacol (2015)

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

af Donthamsetti, Prashant, Konrad, David B., Hetzler, Belinda, Fu, Zhu, Trauner, Dirk, Isacoff, Ehud Y.
Udgivet i J Am Chem Soc (2021)

Amino Acid Architecture That Influences dNTP Insertion Efficiency in Y-Family DNA Polymerase V of E. coli

af Seo, Kwang Young, Yin, Jun, Donthamsetti, Prashant, Chandani, Sushil, Lee, Chui Hong, Loechler, Edward L.
Udgivet 2009

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

af Donthamsetti, Prashant C., Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A., Isacoff, Ehud Y., Trauner, Dirk
Udgivet i J Am Chem Soc (2017)

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

af Michino, Mayako, Donthamsetti, Prashant, Beuming, Thijs, Banala, Ashwini, Duan, Lihua, Roux, Thomas, Han, Yang, Trinquet, Eric, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Udgivet 2013

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

af Donthamsetti, Prashant C., Broichhagen, Johannes, Vyklicky, Vojtech, Stanley, Cherise, Fu, Zhu, Visel, Meike, Levitz, Joshua L., Javitch, Jonathan A., Trauner, Dirk, Isacoff, Ehud Y.
Udgivet i J Am Chem Soc (2019)

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

af Farino, Zachary J., Morgenstern, Travis J., Vallaghe, Julie, Gregor, Nathalie, Donthamsetti, Prashant, Harris, Paul E., Pierre, Nicolas, Freyberg, Robin, Charrier-Savournin, Fabienne, Javitch, Jonathan A., Freyberg, Zachary
Udgivet i PLoS One (2016)

Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens

af Marcott, Pamela F, Gong, Sheng, Donthamsetti, Prashant, Grinnell, Steven G., Nelson, Melissa N., Newman, Amy H, Birnbaumer, Lutz, Martemyanov, Kirill A, Javitch, Jonathan A, Ford, Christopher P
Udgivet i Neuron (2018)

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

af Donthamsetti, Prashant, Gallo, Eduardo F., Buck, David C., Stahl, Edward L., Zhu, Ying, Lane, J. Robert, Bohn, Laura M., Neve, Kim A., Kellendonk, Christoph, Javitch, Jonathan A.
Udgivet i Mol Psychiatry (2018)

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

af Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonathan A., Shi, Lei
Udgivet 2012

Optical Control of Lysophosphatidic Acid Signaling

af Morstein, Johannes, Dacheux, Mélanie A., Norman, Derek D., Shemet, Andrej, Donthamsetti, Prashant C., Citir, Mevlut, Frank, James A., Schultz, Carsten, Isacoff, Ehud Y., Parrill, Abby L., Tigyi, Gabor J., Trauner, Dirk
Udgivet i J Am Chem Soc (2020)

A new mechanism of allostery in a G protein-coupled receptor dimer

af Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Udgivet 2014

The role of kinetic context in apparent biased agonism at GPCRs

af Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Udgivet i Nat Commun (2016)

High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice

af Boateng, Comfort A., Bakare, Oluyomi M., Zhan, Jia, Banala, Ashwini K., Burzynski, Caitlin, Pommier, Elie, Keck, Thomas M., Donthamsetti, Prashant, Javitch, Jonathan A., Rais, Rana, Slusher, Barbara S., Xi, Zheng-Xiong, Newman, Amy Hauck
Udgivet i J Med Chem (2015)

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

af Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Udgivet i J Med Chem (2016)

Towards understanding the structural basis of partial agonism at the dopamine D(3) receptor

af Michino, Mayako, Boateng, Comfort A., Donthamsetti, Prashant, Yano, Hideaki, Bakare, Oluyomi M., Bonifazi, Alessandro, Ellenberger, Michael P., Keck, Thomas M., Kumar, Vivek, Zhu, Clare, Verma, Ravi, Deschamps, Jeffrey R., Javitch, Jonathan A., Newman, Amy Hauck, Shi, Lei
Udgivet i J Med Chem (2017)

Optical Control of Sphingosine-1-Phosphate Formation and Function

af Morstein, Johannes, Hill, Rose Z., Novak, Alexander J. E., Feng, Suihan, Norman, Derek D., Donthamsetti, Prashant C., Frank, James A., Harayama, Takeshi, Williams, Benjamin M., Parrill, Abby L., Tigyi, Gabor J., Riezman, Howard, Isacoff, Ehud Y., Bautista, Diana M., Trauner, Dirk
Udgivet i Nat Chem Biol (2019)

New roles for dopamine D(2) and D(3) receptors in pancreatic beta cell insulin secretion

af Farino, Zachary J., Morgenstern, Travis J., Maffei, Antonella, Quick, Matthias, De Solis, Alain J., Wiriyasermkul, Pattama, Freyberg, Robin J., Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P., Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V., Kellendonk, Christoph, Schwartz, Gary J., Sibley, David R., Schmauss, Claudia, Zeltser, Lori M., Moore, Holly, Harris, Paul E., Javitch, Jonathan A., Freyberg, Zachary
Udgivet i Mol Psychiatry (2019)