Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D(2) Receptor Creates an Internalization-defective Receptor

per Clayton, Cecilea C., Donthamsetti, Prashant, Lambert, Nevin A., Javitch, Jonathan A., Neve, Kim A.
Publicat a J Biol Chem (2014)

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

per Michino, Mayako, Beuming, Thijs, Donthamsetti, Prashant, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Publicat a Pharmacol Rev (2015)

Using bioluminescent resonance energy transfer (BRET) to characterize agonist-induced arrestin recruitment to modified and unmodified G protein-coupled receptors (GPCRs)

per Donthamsetti, Prashant, Quejada, Jose Rafael, Javitch, Jonathan A., Gurevich, Vsevolod V., Lambert, Nevin A.
Publicat a Curr Protoc Pharmacol (2015)

Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

per Donthamsetti, Prashant, Konrad, David B., Hetzler, Belinda, Fu, Zhu, Trauner, Dirk, Isacoff, Ehud Y.
Publicat a J Am Chem Soc (2021)

Amino Acid Architecture That Influences dNTP Insertion Efficiency in Y-Family DNA Polymerase V of E. coli

per Seo, Kwang Young, Yin, Jun, Donthamsetti, Prashant, Chandani, Sushil, Lee, Chui Hong, Loechler, Edward L.
Publicat 2009

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist

per Donthamsetti, Prashant C., Winter, Nils, Schönberger, Matthias, Levitz, Joshua, Stanley, Cherise, Javitch, Jonathan A., Isacoff, Ehud Y., Trauner, Dirk
Publicat a J Am Chem Soc (2017)

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

per Michino, Mayako, Donthamsetti, Prashant, Beuming, Thijs, Banala, Ashwini, Duan, Lihua, Roux, Thomas, Han, Yang, Trinquet, Eric, Newman, Amy Hauck, Javitch, Jonathan A., Shi, Lei
Publicat 2013

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor

per Donthamsetti, Prashant C., Broichhagen, Johannes, Vyklicky, Vojtech, Stanley, Cherise, Fu, Zhu, Visel, Meike, Levitz, Joshua L., Javitch, Jonathan A., Trauner, Dirk, Isacoff, Ehud Y.
Publicat a J Am Chem Soc (2019)

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

per Farino, Zachary J., Morgenstern, Travis J., Vallaghe, Julie, Gregor, Nathalie, Donthamsetti, Prashant, Harris, Paul E., Pierre, Nicolas, Freyberg, Robin, Charrier-Savournin, Fabienne, Javitch, Jonathan A., Freyberg, Zachary
Publicat a PLoS One (2016)

Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens

per Marcott, Pamela F, Gong, Sheng, Donthamsetti, Prashant, Grinnell, Steven G., Nelson, Melissa N., Newman, Amy H, Birnbaumer, Lutz, Martemyanov, Kirill A, Javitch, Jonathan A, Ford, Christopher P
Publicat a Neuron (2018)

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

per Donthamsetti, Prashant, Gallo, Eduardo F., Buck, David C., Stahl, Edward L., Zhu, Ying, Lane, J. Robert, Bohn, Laura M., Neve, Kim A., Kellendonk, Christoph, Javitch, Jonathan A.
Publicat a Mol Psychiatry (2018)

Molecular Determinants of Selectivity and Efficacy at the Dopamine D3 Receptor

per Newman, Amy Hauck, Beuming, Thijs, Banala, Ashwini K., Donthamsetti, Prashant, Pongetti, Katherine, LaBounty, Alex, Levy, Benjamin, Cao, Jianjing, Michino, Mayako, Luedtke, Robert R., Javitch, Jonathan A., Shi, Lei
Publicat 2012

Optical Control of Lysophosphatidic Acid Signaling

per Morstein, Johannes, Dacheux, Mélanie A., Norman, Derek D., Shemet, Andrej, Donthamsetti, Prashant C., Citir, Mevlut, Frank, James A., Schultz, Carsten, Isacoff, Ehud Y., Parrill, Abby L., Tigyi, Gabor J., Trauner, Dirk
Publicat a J Am Chem Soc (2020)

A new mechanism of allostery in a G protein-coupled receptor dimer

per Lane, J. Robert, Donthamsetti, Prashant, Shonberg, Jeremy, Draper-Joyce, Christopher J., Dentry, Samuel, Michino, Mayako, Shi, Lei, López, Laura, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Javitch, Jonathan A., Christopoulos, Arthur
Publicat 2014

The role of kinetic context in apparent biased agonism at GPCRs

per Klein Herenbrink, Carmen, Sykes, David A., Donthamsetti, Prashant, Canals, Meritxell, Coudrat, Thomas, Shonberg, Jeremy, Scammells, Peter J., Capuano, Ben, Sexton, Patrick M., Charlton, Steven J., Javitch, Jonathan A., Christopoulos, Arthur, Lane, J. Robert
Publicat a Nat Commun (2016)

High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice

per Boateng, Comfort A., Bakare, Oluyomi M., Zhan, Jia, Banala, Ashwini K., Burzynski, Caitlin, Pommier, Elie, Keck, Thomas M., Donthamsetti, Prashant, Javitch, Jonathan A., Rais, Rana, Slusher, Barbara S., Xi, Zheng-Xiong, Newman, Amy Hauck
Publicat a J Med Chem (2015)

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D(2)/D(3) Receptor Agonist Selectivity

per Zou, Mu-Fa, Keck, Thomas M., Kumar, Vivek, Donthamsetti, Prashant, Michino, Mayako, Burzynski, Caitlin, Schweppe, Catherine, Bonifazi, Alessandro, Free, R. Benjamin, Sibley, David R., Janowsky, Aaron, Shi, Lei, Javitch, Jonathan A., Newman, Amy Hauck
Publicat a J Med Chem (2016)

Towards understanding the structural basis of partial agonism at the dopamine D(3) receptor

per Michino, Mayako, Boateng, Comfort A., Donthamsetti, Prashant, Yano, Hideaki, Bakare, Oluyomi M., Bonifazi, Alessandro, Ellenberger, Michael P., Keck, Thomas M., Kumar, Vivek, Zhu, Clare, Verma, Ravi, Deschamps, Jeffrey R., Javitch, Jonathan A., Newman, Amy Hauck, Shi, Lei
Publicat a J Med Chem (2017)

Optical Control of Sphingosine-1-Phosphate Formation and Function

per Morstein, Johannes, Hill, Rose Z., Novak, Alexander J. E., Feng, Suihan, Norman, Derek D., Donthamsetti, Prashant C., Frank, James A., Harayama, Takeshi, Williams, Benjamin M., Parrill, Abby L., Tigyi, Gabor J., Riezman, Howard, Isacoff, Ehud Y., Bautista, Diana M., Trauner, Dirk
Publicat a Nat Chem Biol (2019)

New roles for dopamine D(2) and D(3) receptors in pancreatic beta cell insulin secretion

per Farino, Zachary J., Morgenstern, Travis J., Maffei, Antonella, Quick, Matthias, De Solis, Alain J., Wiriyasermkul, Pattama, Freyberg, Robin J., Aslanoglou, Despoina, Sorisio, Denise, Inbar, Benjamin P., Free, R. Benjamin, Donthamsetti, Prashant, Mosharov, Eugene V., Kellendonk, Christoph, Schwartz, Gary J., Sibley, David R., Schmauss, Claudia, Zeltser, Lori M., Moore, Holly, Harris, Paul E., Javitch, Jonathan A., Freyberg, Zachary
Publicat a Mol Psychiatry (2019)