p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal

Por Zhao, Zhen, Zuber, Johannes, Diaz-Flores, Ernesto, Lintault, Laura, Kogan, Scott C., Shannon, Kevin, Lowe, Scott W.
Publicado em 2010

K-Ras(G12D) expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

Por Van Meter, Margaret E. M., Díaz-Flores, Ernesto, Archard, Joehleen A., Passegué, Emmanuelle, Irish, Jonathan M., Kotecha, Nikesh, Nolan, Garry P., Shannon, Kevin, Braun, Benjamin S.
Publicado em 2007

Abnormal hematopoiesis in Gab2 mutant mice

Por Zhang, Yi, Diaz-Flores, Ernesto, Li, Geqiang, Wang, Zhengqi, Kang, Zizhen, Haviernikova, Eleonora, Rowe, Sara, Qu, Cheng-Kui, Tse, William, Shannon, Kevin M., Bunting, Kevin D.
Publicado em 2007

Single Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

Por Kotecha, Nikesh, Flores, Nikki J, Irish, Jonathan M, Simonds, Erin, Sakai, Debbie S., Archambeault, Sophie, Diaz-Flores, Ernesto, Coram, Marc, Shannon, Kevin M, Nolan, Garry P, Loh, Mignon L
Publicado em 2008

Phospholipase C γ and Phosphoinositide 3-Kinase Link Cytokines to ERK Activation in Hematopoietic Cells With Normal and Oncogenic Kras

Por Diaz-Flores, Ernesto, Goldschmidt, Hana, Depeille, Philippe, Ng, Victor, Akutagawa, Jon, Krisman, Kimberly, Crone, Michael, Burgess, Michael R., Williams, Olusegun, Houseman, Benjamin, Shokat, Kevan, Sampath, Deepak, Bollag, Gideon, Roose, Jeroen P., Braun, Benjamin S., Shannon, Kevin
Publicado em 2013

Cooperative loss of RAS feedback regulation drives myeloid leukemognesis

Por Zhao, Zhen, Chen, Chi-Chao, Rillahan, Cory D., Shen, Ronglai, Kitzing, Thomas, McNerney, Megan E., Diaz-Flores, Ernesto, Zuber, Johannes, Shannon, Kevin, Le Beau, Michelle M., Spector, Mona S., Kogan, Scott C., Lowe, Scott W.
Publicado no Nat Genet (2015)

NRAS(G12V) oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia

Por Sachs, Zohar, LaRue, Rebecca S., Nguyen, Hanh T., Sachs, Karen, Noble, Klara E., Mohd Hassan, Nurul Azyan, Diaz-Flores, Ernesto, Rathe, Susan K., Sarver, Aaron L., Bendall, Sean C., Ha, Ngoc A., Diers, Miechaleen D., Nolan, Garry P., Shannon, Kevin M., Largaespada, David A.
Publicado no Blood (2014)

Response and Resistance to MEK Inhibition in Leukaemias Initiated by Hyperactive Ras

Por Lauchle, Jennifer O., Kim, Doris, Le, Doan T., Akagi, Keiko, Crone, Michael, Krisman, Kimberly, Warner, Kegan, Bonifas, Jeannette M., Li, Qing, Coakley, Kristin M., Diaz-Flores, Ernesto, Gorman, Matthew, Przybranowski, Sally, Tran, Mary, Kogan, Scott C., Roose, Jeroen P., Copeland, Neal, Jenkins, Nancy, Parada, Luis, Wolff, Linda, Sebolt-Leopold, Judith, Shannon, Kevin
Publicado em 2009

Stat5 is critical for the development and maintenance of myeloproliferative neoplasm initiated by Nf1 deficiency

Por Sachs, Zohar, Been, Raha A., DeCoursin, Krista J., Nguyen, Hanh T., Mohd Hassan, Nurul A., Noble-Orcutt, Klara E., Eckfeldt, Craig E., Pomeroy, Emily J., Diaz-Flores, Ernesto, Geurts, Jennifer L., Diers, Miechaleen D., Hasz, Diane E., Morgan, Kelly J., MacMillan, Margaret L., Shannon, Kevin M., Largaespada, David A., Wiesner, Stephen M.
Publicado no Haematologica (2016)

Phase II Study of the Oral Mek Inhibitor Selumetinib in Advanced Acute Myeloid Leukemia (AML): A University of Chicago Phase II Consortium Trial

Por Jain, Nitin, Curran, Emily, Iyengar, Neil M., Diaz-Flores, Ernesto, Kunnavakkam, Rangesh, Popplewell, Leslie, Kirschbaum, Mark H., Karrison, Theodore, Erba, Harry P., Green, Margaret, Poire, Xavier, Koval, Greg, Shannon, Kevin, Reddy, Poluru L., Joseph, Loren, Atallah, Ehab L., Dy, Philip, Thomas, Sachdev P., Smith, Scott E., Doyle, L. Austin, Stadler, Walter M., Larson, Richard A., Stock, Wendy, Odenike, Olatoyosi
Publicado no Clin Cancer Res (2013)

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Por Frismantas, Viktoras, Dobay, Maria Pamela, Rinaldi, Anna, Tchinda, Joelle, Dunn, Samuel H., Kunz, Joachim, Richter-Pechanska, Paulina, Marovca, Blerim, Pail, Orrin, Jenni, Silvia, Diaz-Flores, Ernesto, Chang, Bill H., Brown, Timothy J., Collins, Robert H., Uhrig, Sebastian, Balasubramanian, Gnana P., Bandapalli, Obul R., Higi, Salome, Eugster, Sabrina, Voegeli, Pamela, Delorenzi, Mauro, Cario, Gunnar, Loh, Mignon L., Schrappe, Martin, Stanulla, Martin, Kulozik, Andreas E., Muckenthaler, Martina U., Saha, Vaskar, Irving, Julie A., Meisel, Roland, Radimerski, Thomas, Von Stackelberg, Arend, Eckert, Cornelia, Tyner, Jeffrey W., Horvath, Peter, Bornhauser, Beat C., Bourquin, Jean-Pierre
Publicado no Blood (2017)

THE GENOMIC LANDSCAPE OF HYPODIPLOID ACUTE LYMPHOBLASTIC LEUKEMIA

Por Holmfeldt, Linda, Wei, Lei, Diaz-Flores, Ernesto, Walsh, Michael, Zhang, Jinghui, Ding, Li, Payne-Turner, Debbie, Churchman, Michelle, Andersson, Anna, Chen, Shann-Ching, McCastlain, Kelly, Becksfort, Jared, Ma, Jing, Wu, Gang, Patel, Samir N., Heatley, Susan L., Phillips, Letha A., Song, Guangchun, Easton, John, Parker, Matthew, Chen, Xiang, Rusch, Michael, Boggs, Kristy, Vadodaria, Bhavin, Hedlund, Erin, Drenberg, Christina, Baker, Sharyn, Pei, Deqing, Cheng, Cheng, Huether, Robert, Lu, Charles, Fulton, Robert S., Fulton, Lucinda L., Tabib, Yashodhan, Dooling, David J., Ochoa, Kerri, Minden, Mark, Lewis, Ian D., To, L. Bik, Marlton, Paula, Roberts, Andrew W., Raca, Gordana, Stock, Wendy, Neale, Geoffrey, Drexler, Hans G., Dickins, Ross A., Ellison, David W., Shurtleff, Sheila A., Pui, Ching-Hon, Ribeiro, Raul C., Devidas, Meenakshi, Carroll, Andrew J., Heerema, Nyla A., Wood, Brent, Borowitz, Michael J., Gastier-Foster, Julie M., Raimondi, Susana C., Mardis, Elaine R., Wilson, Richard K., Downing, James R., Hunger, Stephen P., Loh, Mignon L., Mullighan, Charles G.
Publicado em 2013