K-Ras(G12D) expression induces hyperproliferation and aberrant signaling in primary hematopoietic stem/progenitor cells

Defining how cancer-associated mutations perturb signaling networks in stem/progenitor populations that are integral to tumor formation and maintenance is a fundamental problem with biologic and clinical implications. Point mutations in RAS genes contribute to many cancers, including myeloid maligna...

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Detalhes bibliográficos
Main Authors: Van Meter, Margaret E. M., Díaz-Flores, Ernesto, Archard, Joehleen A., Passegué, Emmanuelle, Irish, Jonathan M., Kotecha, Nikesh, Nolan, Garry P., Shannon, Kevin, Braun, Benjamin S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2007
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1874575/
https://ncbi.nlm.nih.gov/pubmed/17192389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-047530
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