Survivin mediates aberrant hematopoietic progenitor cell proliferation and acute leukemia in mice induced by internal tandem duplication of Flt3

Internal tandem duplication mutations in the Flt3 tyrosine kinase gene (ITD-Flt3) and overexpression of Survivin are frequently found in patients with acute myeloid leukemia (AML). We investigated whether Survivin mediates the enhanced survival of primary hematopoietic progenitor cells (HPCs) result...

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Bibliographic Details
Main Authors: Fukuda, Seiji, Singh, Pratibha, Moh, Akira, Abe, Mariko, Conway, Edward M., Boswell, H. Scott, Yamaguchi, Seiji, Fu, Xin-Yuan, Pelus, Louis M.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2714213/
https://ncbi.nlm.nih.gov/pubmed/19411632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-11-188714
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