Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells

Internal tandem duplication (ITD) mutations in the Fms-related tyrosine kinase 3 (FLT3) gene (FLT3-ITD) are associated with poor prognosis in patients with acute myeloid leukemia (AML). Due to the development of drug resistance, few FLT3-ITD inhibitors are effective against FLT3-ITD(+) AML. In this...

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Vydáno v:PLoS One
Hlavní autoři: Abe, Mariko, Pelus, Louis M., Singh, Pratibha, Hirade, Tomohiro, Onishi, Chie, Purevsuren, Jamiyan, Taketani, Takeshi, Yamaguchi, Seiji, Fukuda, Seiji
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936702/
https://ncbi.nlm.nih.gov/pubmed/27387666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158290
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