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Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells

Internal tandem duplication (ITD) mutations in the Fms-related tyrosine kinase 3 (FLT3) gene (FLT3-ITD) are associated with poor prognosis in patients with acute myeloid leukemia (AML). Due to the development of drug resistance, few FLT3-ITD inhibitors are effective against FLT3-ITD(+) AML. In this...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Abe, Mariko, Pelus, Louis M., Singh, Pratibha, Hirade, Tomohiro, Onishi, Chie, Purevsuren, Jamiyan, Taketani, Takeshi, Yamaguchi, Seiji, Fukuda, Seiji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936702/
https://ncbi.nlm.nih.gov/pubmed/27387666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158290
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