Internal Tandem Duplication Mutations in FLT3 Gene Augment Chemotaxis to Cxcl12 Protein by Blocking the Down-regulation of the Rho-associated Kinase via the Cxcl12/Cxcr4 Signaling Axis

Internal tandem duplication mutations in the Flt3 gene (ITD-FLT3) enhance cell migration toward the chemokine Cxcl12, which is highly expressed in the therapy-protective bone marrow niche, providing a potential mechanism underlying the poor prognosis of ITD-FLT3(+) acute myeloid leukemia. We aimed t...

Full description

Saved in:
Bibliographic Details
Published in:J Biol Chem
Main Authors: Onish, Chie, Mori-Kimachi, Satomi, Hirade, Tomohiro, Abe, Mariko, Taketani, Takeshi, Suzumiya, Junji, Sugimoto, Toshitsugu, Yamaguchi, Seiji, Kapur, Reuben, Fukuda, Seiji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223310/
https://ncbi.nlm.nih.gov/pubmed/25237195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.568287
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items