Deubiquitination of CXCR4 by USP14 Is Critical for Both CXCL12-induced CXCR4 Degradation and Chemotaxis but Not ERK Activation

The chemokine receptor CXCR4 plays important roles in the immune and nervous systems. Abnormal expression of CXCR4 contributes to cancer and inflammatory and neurodegenerative disorders. Although ligand-dependent CXCR4 ubiquitination is known to accelerate CXCR4 degradation, little is known about co...

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Hlavní autoři: Mines, Marjelo A., Goodwin, J. Shawn, Limbird, Lee E., Cui, Fei-Fei, Fan, Guo-Huang
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645827/
https://ncbi.nlm.nih.gov/pubmed/19106094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808507200
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