Internal Tandem Duplication in FLT3 Attenuates Proliferation and Regulates Resistance to the FLT3 Inhibitor AC220 by Modulating p21(Cdkn1a) and Pbx1 in Hematopoietic Cells

Internal tandem duplication (ITD) mutations in the Fms-related tyrosine kinase 3 (FLT3) gene (FLT3-ITD) are associated with poor prognosis in patients with acute myeloid leukemia (AML). Due to the development of drug resistance, few FLT3-ITD inhibitors are effective against FLT3-ITD(+) AML. In this...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:PLoS One
Autores principales: Abe, Mariko, Pelus, Louis M., Singh, Pratibha, Hirade, Tomohiro, Onishi, Chie, Purevsuren, Jamiyan, Taketani, Takeshi, Yamaguchi, Seiji, Fukuda, Seiji
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4936702/
https://ncbi.nlm.nih.gov/pubmed/27387666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158290
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares