Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells

ITD-Flt3 mutations are detected in leukemia stem cells (LSCs) in acute myeloid leukemia (AML) patients. While antagonizing Survivin normalizes ITD-Flt3-induced acute leukemia, it also impairs hematopoietic stem cell (HSC) function, indicating that identification of differences in signaling pathways...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fukuda, Seiji, Abe, Mariko, Onishi, Chie, Taketani, Takeshi, Purevsuren, Jamiyan, Yamaguchi, Seiji, Conway, Edward M., Pelus, Louis M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi Publishing Corporation 2011
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021862/
https://ncbi.nlm.nih.gov/pubmed/21253548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/946936
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