Survivin Selectively Modulates Genes Deregulated in Human Leukemia Stem Cells

ITD-Flt3 mutations are detected in leukemia stem cells (LSCs) in acute myeloid leukemia (AML) patients. While antagonizing Survivin normalizes ITD-Flt3-induced acute leukemia, it also impairs hematopoietic stem cell (HSC) function, indicating that identification of differences in signaling pathways...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Fukuda, Seiji, Abe, Mariko, Onishi, Chie, Taketani, Takeshi, Purevsuren, Jamiyan, Yamaguchi, Seiji, Conway, Edward M., Pelus, Louis M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi Publishing Corporation 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3021862/
https://ncbi.nlm.nih.gov/pubmed/21253548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/946936
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge