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Survivin Modulates Genes with Divergent Molecular Functions and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

The inhibitor of apoptosis protein Survivin regulates hematopoiesis, although its mechanisms of regulation of hematopoietic stem cells (HSCs) remain largely unknown. While investigating conditional Survivin deletion in mice, we found that Survivin was highly expressed in phenotypically defined HSCs...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Fukuda, Seiji, Hoggatt, Jonathan, Singh, Pratibha, Abe, Mariko, Speth, Jennifer M., Hu, Peirong, Conway, Edward M., Nucifora, Giuseppina, Yamaguchi, Seiji, Pelus, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258188/
https://ncbi.nlm.nih.gov/pubmed/24903482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.183
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