Survivin Modulates Genes with Divergent Molecular Functions and Regulates Proliferation of Hematopoietic Stem Cells through Evi-1

The inhibitor of apoptosis protein Survivin regulates hematopoiesis, although its mechanisms of regulation of hematopoietic stem cells (HSCs) remain largely unknown. While investigating conditional Survivin deletion in mice, we found that Survivin was highly expressed in phenotypically defined HSCs...

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Publicado en:Leukemia
Main Authors: Fukuda, Seiji, Hoggatt, Jonathan, Singh, Pratibha, Abe, Mariko, Speth, Jennifer M., Hu, Peirong, Conway, Edward M., Nucifora, Giuseppina, Yamaguchi, Seiji, Pelus, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258188/
https://ncbi.nlm.nih.gov/pubmed/24903482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.183
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