Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

The MLL-partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. However, mice expressing either Mll-PTD or Flt3-ITD do not develop AM...

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Hauptverfasser: Zorko, Nicholas A., Bernot, Kelsie M., Whitman, Susan P., Siebenaler, Ronald F., Ahmed, Elshafa H., Marcucci, Gabriele G., Yanes, Daniel A., McConnell, Kathleen K., Mao, Charlene, Kalu, Chidimma, Zhang, Xiaoli, Jarjoura, David, Dorrance, Adrienne M., Heerema, Nyla A., Lee, Benjamin H., Huang, Gang, Marcucci, Guido, Caligiuri, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412333/
https://ncbi.nlm.nih.gov/pubmed/22674806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415067
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