Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

The MLL-partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. However, mice expressing either Mll-PTD or Flt3-ITD do not develop AM...

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Detalhes bibliográficos
Main Authors: Zorko, Nicholas A., Bernot, Kelsie M., Whitman, Susan P., Siebenaler, Ronald F., Ahmed, Elshafa H., Marcucci, Gabriele G., Yanes, Daniel A., McConnell, Kathleen K., Mao, Charlene, Kalu, Chidimma, Zhang, Xiaoli, Jarjoura, David, Dorrance, Adrienne M., Heerema, Nyla A., Lee, Benjamin H., Huang, Gang, Marcucci, Guido, Caligiuri, Michael A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412333/
https://ncbi.nlm.nih.gov/pubmed/22674806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415067
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