Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias

The MLL-partial tandem duplication (PTD) associates with high-risk cytogenetically normal acute myeloid leukemia (AML). Concurrent presence of FLT3-internal tandem duplication (ITD) is observed in 25% of patients with MLL-PTD AML. However, mice expressing either Mll-PTD or Flt3-ITD do not develop AM...

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Autors principals: Zorko, Nicholas A., Bernot, Kelsie M., Whitman, Susan P., Siebenaler, Ronald F., Ahmed, Elshafa H., Marcucci, Gabriele G., Yanes, Daniel A., McConnell, Kathleen K., Mao, Charlene, Kalu, Chidimma, Zhang, Xiaoli, Jarjoura, David, Dorrance, Adrienne M., Heerema, Nyla A., Lee, Benjamin H., Huang, Gang, Marcucci, Guido, Caligiuri, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Myeloid Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412333/
https://ncbi.nlm.nih.gov/pubmed/22674806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-415067
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