Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells

One mechanism for disrupting the MLL gene in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) is through partial tandem duplication (MLL-PTD); however, the mechanism by which MLL-PTD contributes to MDS and AML development and maintenance is currently unknown. Herein, we investigated h...

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Autori principali: Zhang, Yue, Yan, Xiaomei, Sashida, Goro, Zhao, Xinghui, Rao, Yalan, Goyama, Susumu, Whitman, Susan P., Zorko, Nicholas, Bernot, Kelsie, Conway, Rajeana M., Witte, David, Wang, Qian-fei, Tenen, Daniel G., Xiao, Zhijian, Marcucci, Guido, Mulloy, James C., Grimes, H. Leighton, Caligiuri, Michael A., Huang, Gang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2012
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412332/
https://ncbi.nlm.nih.gov/pubmed/22740449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-02-412379
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