Eradicating acute myeloid leukemia in a Mll(PTD/wt):Flt3(ITD/wt) murine model: a path to novel therapeutic approaches for human disease

The coexpression of the MLL partial tandem duplication (PTD) and the FLT3 internal tandem duplication (ITD) mutations associate with a poor outcome in cytogenetically normal acute myeloid leukemia (AML). In mice, a double knock-in (dKI) of Mll(PTD/wt) and Flt3(ITD/wt) mutations induces spontaneous A...

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Detalhes bibliográficos
Main Authors: Bernot, Kelsie M., Nemer, John S., Santhanam, Ramasamy, Liu, Shujun, Zorko, Nicholas A., Whitman, Susan P., Dickerson, Kathryn E., Zhang, Mengzi, Yang, Xiaojuan, McConnell, Kathleen K., Ahmed, Elshafa H., Muñoz, Maura R., Siebenaler, Ronald F., Marcucci, Gabriel G., Mundy-Bosse, Bethany L., Brook, Daniel L., Garman, Sabrina, Dorrance, Adrienne M., Zhang, Xiaoli, Zhang, Jianying, Lee, Robert J., Blum, William, Caligiuri, Michael A., Marcucci, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3843236/
https://ncbi.nlm.nih.gov/pubmed/24085765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-06-507426
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