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The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele
The partial tandem duplication of MLL (MLL-PTD) is found in 5% to 10% of patients with acute myeloid leukemia (AML) and normal cytogenetics. Its expression in leukemic blasts is coincident with a silenced wild-type (WT) MLL allele. We therefore generated mice expressing the Mll-PTD in the absence of...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2532816/ https://ncbi.nlm.nih.gov/pubmed/18617636 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-134338 |
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