The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele

The partial tandem duplication of MLL (MLL-PTD) is found in 5% to 10% of patients with acute myeloid leukemia (AML) and normal cytogenetics. Its expression in leukemic blasts is coincident with a silenced wild-type (WT) MLL allele. We therefore generated mice expressing the Mll-PTD in the absence of...

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Hlavní autoři: Dorrance, Adrienne M., Liu, Shujun, Chong, Anita, Pulley, Benjamin, Nemer, David, Guimond, Martin, Yuan, Weifeng, Chang, Dennis, Whitman, Susan P., Marcucci, Guido, Caligiuri, Michael A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2008
Témata:
Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2532816/
https://ncbi.nlm.nih.gov/pubmed/18617636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-01-134338
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