The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloid leukemia (AML) blasts with the t(9;11)(p22; q23) express MLL-AF9 and MLL wild-type (WT) transcripts, while normal karyotype AML blasts with the MLL(...

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Hauptverfasser: Whitman, Susan P., Liu, Shujun, Vukosavljevic, Tamara, Rush, Laura J., Yu, Li, Liu, Chunhui, Klisovic, Marko I., Maharry, Kati, Guimond, Martin, Strout, Matthew P., Becknell, Brian, Dorrance, Adrienne, Klisovic, Rebecca B., Plass, Christoph, Bloomfield, Clara D., Marcucci, Guido, Caligiuri, Michael A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2005 by The American Society of Hematology 2005
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895129/
https://ncbi.nlm.nih.gov/pubmed/15774615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0204
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