The MLL partial tandem duplication: evidence for recessive gain-of-function in acute myeloid leukemia identifies a novel patient subgroup for molecular-targeted therapy

MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have mechanistically distinct contributions to leukemogenesis. Acute myeloid leukemia (AML) blasts with the t(9;11)(p22; q23) express MLL-AF9 and MLL wild-type (WT) transcripts, while normal karyotype AML blasts with the MLL(...

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Bibliografiska uppgifter
Huvudupphovsmän: Whitman, Susan P., Liu, Shujun, Vukosavljevic, Tamara, Rush, Laura J., Yu, Li, Liu, Chunhui, Klisovic, Marko I., Maharry, Kati, Guimond, Martin, Strout, Matthew P., Becknell, Brian, Dorrance, Adrienne, Klisovic, Rebecca B., Plass, Christoph, Bloomfield, Clara D., Marcucci, Guido, Caligiuri, Michael A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: © 2005 by The American Society of Hematology 2005
Ämnen:
Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895129/
https://ncbi.nlm.nih.gov/pubmed/15774615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-01-0204
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