Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

RUNX1/CBFβ (core binding factor [CBF]) is a heterodimeric transcription factor complex that is frequently involved in chromosomal translocations, point mutations, or deletions in acute leukemia. The mixed lineage leukemia (MLL) gene is also frequently involved in chromosomal translocations or partia...

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Main Authors: Zhao, Xinghui, Chen, Aili, Yan, Xiaomei, Zhang, Yue, He, Fuhong, Hayashi, Yoshihiro, Dong, Yunzhu, Rao, Yalan, Li, Bo, Conway, Rajeana M., Maiques-Diaz, Alba, Elf, Shannon E., Huang, Nuomin, Zuber, Johannes, Xiao, Zhijian, Tse, William, Tenen, Daniel G., Wang, Qianfei, Chen, Wei, Mulloy, James C., Nimer, Stephen D., Huang, Gang
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2014
Ábhair:
Myeloid Neoplasia
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067497/
https://ncbi.nlm.nih.gov/pubmed/24449215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-489575
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