Downregulation of RUNX1/CBFβ by MLL fusion proteins enhances hematopoietic stem cell self-renewal

RUNX1/CBFβ (core binding factor [CBF]) is a heterodimeric transcription factor complex that is frequently involved in chromosomal translocations, point mutations, or deletions in acute leukemia. The mixed lineage leukemia (MLL) gene is also frequently involved in chromosomal translocations or partia...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Zhao, Xinghui, Chen, Aili, Yan, Xiaomei, Zhang, Yue, He, Fuhong, Hayashi, Yoshihiro, Dong, Yunzhu, Rao, Yalan, Li, Bo, Conway, Rajeana M., Maiques-Diaz, Alba, Elf, Shannon E., Huang, Nuomin, Zuber, Johannes, Xiao, Zhijian, Tse, William, Tenen, Daniel G., Wang, Qianfei, Chen, Wei, Mulloy, James C., Nimer, Stephen D., Huang, Gang
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2014
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4067497/
https://ncbi.nlm.nih.gov/pubmed/24449215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-03-489575
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