Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice

The core-binding factor (CBF) is a master regulator of developmental and differentiation programs, and CBF alterations are frequently associated with acute leukemia. The role of the CBF member RUNX2 in hematopoiesis is poorly understood. Genetic evidence suggests that deregulation of Runx2 may cause...

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Autori principali: Kuo, Ya-Huei, Zaidi, Sayyed K., Gornostaeva, Svetlana, Komori, Toshihisa, Stein, Gary S., Castilla, Lucio H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2009
Soggetti:
Myeloid Neoplasia
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665897/
https://ncbi.nlm.nih.gov/pubmed/19179305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2008-06-162248
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