Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling

Oncogenic mutations in components of cytokine signaling pathways elicit ligand-independent activation of downstream signaling, enhancing proliferation and survival in acute myeloid leukemia (AML). The myeloproliferative leukemia virus oncogene, MPL, a homodimeric receptor activated by thrombopoietin...

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Hlavní autoři: Pulikkan, John Anto, Madera, Dmitri, Xue, Liting, Bradley, Paul, Landrette, Sean Francis, Kuo, Ya-Huei, Abbas, Saman, Zhu, Lihua Julie, Valk, Peter, Castilla, Lucio Hernán
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2012
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3412349/
https://ncbi.nlm.nih.gov/pubmed/22613795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-414649
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