The thrombopoietin receptor, MPL, is critical for development of a JAK2V(617)F-induced myeloproliferative neoplasm

The most frequent contributing factor in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) is the acquisition of a V(617)F mutation in Janus kinase 2 (JAK2) in hematopoietic stem cells (HSCs). Recent evidence has demonstrated that to drive MPN transformation, JAK2V(617)F needs to...

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Bibliographic Details
Published in:Blood
Main Authors: Sangkhae, Veena, Etheridge, S. Leah, Kaushansky, Kenneth, Hitchcock, Ian S.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2014
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271181/
https://ncbi.nlm.nih.gov/pubmed/25339357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587238
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