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The thrombopoietin receptor, MPL, is critical for development of a JAK2V(617)F-induced myeloproliferative neoplasm
The most frequent contributing factor in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) is the acquisition of a V(617)F mutation in Janus kinase 2 (JAK2) in hematopoietic stem cells (HSCs). Recent evidence has demonstrated that to drive MPN transformation, JAK2V(617)F needs to...
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| Publié dans: | Blood |
|---|---|
| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society of Hematology
2014
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4271181/ https://ncbi.nlm.nih.gov/pubmed/25339357 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-587238 |
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