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JAK2(V617F)-mutant Vascular Niche Contributes to JAK2(V617F) Clonal Expansion in Myeloproliferative Neoplasms

The myeloproliferative neoplasms (MPNs) are characterized by hematopoietic stem/progenitor cell (HSPC) expansion and overproduction of blood cells. The acquired mutation JAK2(V617F) plays a central role in these disorders. Mechanisms responsible for MPN HSPC expansion is not fully understood, limiti...

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Detalhes bibliográficos
Publicado no:Blood Cells Mol Dis
Main Authors: Lin, Chi Hua Sarah, Kaushansky, Kenneth, Zhan, Huichun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135612/
https://ncbi.nlm.nih.gov/pubmed/27865175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2016.09.004
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