Endothelial JAK2V617F mutation leads to thrombosis, vasculopathy, and cardiomyopathy in a murine model of myeloproliferative neoplasm

OBJECTIVE: Cardiovascular complications are the leading cause of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs). The acquired kinase mutation JAK2V617F plays a central role in these disorders. Mechanisms responsible for cardiovascular dysfunction in MPNs are not fully u...

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Detalhes bibliográficos
Publicado no:J Thromb Haemost
Main Authors: Castiglione, Melissa, Jiang, Ya‐Ping, Mazzeo, Christopher, Lee, Sandy, Chen, Juei‐Suei, Kaushansky, Kenneth, Yin, Wei, Lin, Richard Z., Zheng, Haoyi, Zhan, Huichun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
VASCULAR BIOLOGY
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756295/
https://ncbi.nlm.nih.gov/pubmed/32920974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.15095
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