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Nras(G12D) oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Acute myeloid leukemia (AML) results from the activity of driver mutations that deregulate proliferation and survival of hematopoietic stem cells (HSCs). The fusion protein CBFβ-SMMHC impairs differentiation in hematopoietic stem and progenitor cells and induces AML in cooperation with other mutatio...

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Autors principals: Xue, Liting, Pulikkan, John A., Valk, Peter J. M., Castilla, Lucio H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4102713/
https://ncbi.nlm.nih.gov/pubmed/24894773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-12-541730
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