Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development

Por Kuo, Ya-Huei, Gerstein, Rachel M., Castilla, Lucio H.
Publicado em 2008

The PlagL2 transcription factor activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells

Por Landrette, Sean F, Madera, Dmitri, He, Feng, Castilla, Lucio H
Publicado em 2011

Nras(G12D) oncoprotein inhibits apoptosis of preleukemic cells expressing Cbfβ-SMMHC via activation of MEK/ERK axis

Por Xue, Liting, Pulikkan, John A., Valk, Peter J. M., Castilla, Lucio H.
Publicado em 2014

Selection of Early-Occurring Mutations Dictates Hormone-Independent Progression in Mouse Mammary Tumor Lines

Por Gattelli, Albana, Zimberlin, María N., Meiss, Roberto P., Castilla, Lucio H., Kordon, Edith C.
Publicado em 2006

Runx2 induces acute myeloid leukemia in cooperation with Cbfβ-SMMHC in mice

Por Kuo, Ya-Huei, Zaidi, Sayyed K., Gornostaeva, Svetlana, Komori, Toshihisa, Stein, Gary S., Castilla, Lucio H.
Publicado em 2009

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus

Por Zhao, Ling, Cannons, Jennifer L., Anderson, Stacie, Kirby, Martha, Xu, Liping, Castilla, Lucio H., Schwartzberg, Pamela L., Bosselut, Rémy, Liu, P. Paul
Publicado em 2007

Impaired granulopoiesis, myelodysplasia, and early lethality in CCAAT/enhancer binding protein ɛ-deficient mice

Por Yamanaka, Ryuya, Barlow, Carrolee, Lekstrom-Himes, Julie, Castilla, Lucio H., Liu, Pu P., Eckhaus, Michael, Decker, Thomas, Wynshaw-Boris, Anthony, Xanthopoulos, Kleanthis G.
Publicado em 1997

A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Por Illendula, Anuradha, Pulikkan, John A., Zong, Hongliang, Grembecka, Jolanta, Xue, Liting, Sen, Siddhartha, Zhou, Yunpeng, Boulton, Adam, Kuntimaddi, Aravinda, Gao, Yan, Rajewski, Roger A., Guzman, Monica L., Castilla, Lucio H., Bushweller, John H.
Publicado no Science (2015)

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Por Illendula, Anuradha, Gilmour, Jane, Grembecka, Jolanta, Tirumala, Venkata Sesha Srimath, Boulton, Adam, Kuntimaddi, Aravinda, Schmidt, Charles, Wang, Lixin, Pulikkan, John A., Zong, Hongliang, Parlak, Mahmut, Kuscu, Cem, Pickin, Anna, Zhou, Yunpeng, Gao, Yan, Mishra, Lauren, Adli, Mazhar, Castilla, Lucio H., Rajewski, Roger A., Janes, Kevin A., Guzman, Monica L., Bonifer, Constanze, Bushweller, John H.
Publicado no EBioMedicine (2016)