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A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice
Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcrip...
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| Publicado en: | Science |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4423805/ https://ncbi.nlm.nih.gov/pubmed/25678665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0314 |
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