A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcrip...

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Foilsithe in:Science
Main Authors: Illendula, Anuradha, Pulikkan, John A., Zong, Hongliang, Grembecka, Jolanta, Xue, Liting, Sen, Siddhartha, Zhou, Yunpeng, Boulton, Adam, Kuntimaddi, Aravinda, Gao, Yan, Rajewski, Roger A., Guzman, Monica L., Castilla, Lucio H., Bushweller, John H.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423805/
https://ncbi.nlm.nih.gov/pubmed/25678665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0314
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