A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcrip...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Science
Main Authors: Illendula, Anuradha, Pulikkan, John A., Zong, Hongliang, Grembecka, Jolanta, Xue, Liting, Sen, Siddhartha, Zhou, Yunpeng, Boulton, Adam, Kuntimaddi, Aravinda, Gao, Yan, Rajewski, Roger A., Guzman, Monica L., Castilla, Lucio H., Bushweller, John H.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423805/
https://ncbi.nlm.nih.gov/pubmed/25678665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0314
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares