A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice

Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy chain), expressed in AML with the chromosome inversion inv(16)(p13q22), outcompetes wild-type CBFβ for binding to the transcrip...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Science
मुख्य लेखकों: Illendula, Anuradha, Pulikkan, John A., Zong, Hongliang, Grembecka, Jolanta, Xue, Liting, Sen, Siddhartha, Zhou, Yunpeng, Boulton, Adam, Kuntimaddi, Aravinda, Gao, Yan, Rajewski, Roger A., Guzman, Monica L., Castilla, Lucio H., Bushweller, John H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4423805/
https://ncbi.nlm.nih.gov/pubmed/25678665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa0314
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