CBFβ-SMMHC inhibition triggers apoptosis by disrupting MYC chromatin dynamics in acute myeloid leukemia

The fusion oncoprotein CBFβ-SMMHC, expressed in leukemia cases with chromosome 16 inversion, drives leukemia development and maintenance by altering the activity of the transcription factor RUNX1. Here we demonstrate that CBFβ-SMMHC maintains cell viability by neutralizing RUNX1-mediated repression...

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Publicat a:Cell
Autors principals: Pulikkan, John Anto, Hegde, Mahesh, Ahmad, Hafiz Mohd, Belaghzal, Houda, Illendula, Anuradha, Yu, Jun, O’Hagan, Kelsey, Ou, Jianhong, Muller-Tidow, Carsten, Wolfe, Scot A., Julie Zhu, Lihua, Dekker, Job, Bushweller, John Hackett, Castilla, Lucio Hernán
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6211564/
https://ncbi.nlm.nih.gov/pubmed/29958106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.05.048
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