Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Transcription factors have traditionally been viewed with skepticism as viable drug targets, but they offer the potential for completely novel mechanisms of action that could more effectively address the stem cell like properties, such as self-renewal and chemo-resistance, that lead to the failure o...

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Sparad:
Bibliografiska uppgifter
I publikationen:EBioMedicine
Huvudupphovsmän: Illendula, Anuradha, Gilmour, Jane, Grembecka, Jolanta, Tirumala, Venkata Sesha Srimath, Boulton, Adam, Kuntimaddi, Aravinda, Schmidt, Charles, Wang, Lixin, Pulikkan, John A., Zong, Hongliang, Parlak, Mahmut, Kuscu, Cem, Pickin, Anna, Zhou, Yunpeng, Gao, Yan, Mishra, Lauren, Adli, Mazhar, Castilla, Lucio H., Rajewski, Roger A., Janes, Kevin A., Guzman, Monica L., Bonifer, Constanze, Bushweller, John H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier 2016
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919611/
https://ncbi.nlm.nih.gov/pubmed/27428424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2016.04.032
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