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Characterization of RNA aptamers that disrupt the RUNX1–CBFβ/DNA complex
The transcription factor RUNX1 (AML1) is an important regulator of haematopoiesis, and an important fusion partner in leukaemic translocations. High-affinity DNA binding by RUNX1 requires the interaction of the RUNX1 Runt-Homology-Domain (RHD) with the core-binding factor β protein (CBFβ). To genera...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2777437/ https://ncbi.nlm.nih.gov/pubmed/19740763 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp728 |
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