Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

OBJECTIVE: Ovarian cancer survival and treatment have improved minimally in the past 20 years. Novel treatment strategies are needed to combat this disease. This study investigates the effects of chemical inhibition of the CBFβ/RUNX protein-protein interaction on ovarian cancer cell lines. METHODS:...

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Publicado no:Gynecol Oncol
Main Authors: Carlton, Anne L., Illendula, Anuradha, Gao, Yan, Llaneza, Danielle C., Boulton, Adam, Shah, Anant, Rajewski, Roger A., Landen, Charles N., Wotton, David, Bushweller, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915923/
https://ncbi.nlm.nih.gov/pubmed/29551565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.03.005
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