Small molecule inhibition of the CBFβ/RUNX interaction decreases ovarian cancer growth and migration through alterations in genes related to epithelial-to-mesenchymal transition

OBJECTIVE: Ovarian cancer survival and treatment have improved minimally in the past 20 years. Novel treatment strategies are needed to combat this disease. This study investigates the effects of chemical inhibition of the CBFβ/RUNX protein-protein interaction on ovarian cancer cell lines. METHODS:...

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Опубликовано в: :Gynecol Oncol
Главные авторы: Carlton, Anne L., Illendula, Anuradha, Gao, Yan, Llaneza, Danielle C., Boulton, Adam, Shah, Anant, Rajewski, Roger A., Landen, Charles N., Wotton, David, Bushweller, John H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5915923/
https://ncbi.nlm.nih.gov/pubmed/29551565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.03.005
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