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Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development
The core-binding factor (CBF)–associated leukemia fusion protein CBFβ-SMMHC impairs myeloid and lymphoid differentiation. By inhibiting RUNX function, the fusion oncoprotein predisposes specifically to acute myeloid leukemia in both patients and mouse models. We have shown that Cbfβ-SMMHC expression...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2214760/ https://ncbi.nlm.nih.gov/pubmed/17940206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-104422 |
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