Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development

The core-binding factor (CBF)–associated leukemia fusion protein CBFβ-SMMHC impairs myeloid and lymphoid differentiation. By inhibiting RUNX function, the fusion oncoprotein predisposes specifically to acute myeloid leukemia in both patients and mouse models. We have shown that Cbfβ-SMMHC expression...

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Autors principals: Kuo, Ya-Huei, Gerstein, Rachel M., Castilla, Lucio H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2008
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214760/
https://ncbi.nlm.nih.gov/pubmed/17940206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-07-104422
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